Active
Stratum Nightly Active 0.1%
Made by Stratum
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Price:
$38 (Mid-range)
Scientific Evidence:
Excellent
Feedback from Stratum users and across the web
9.6/10
(7)
Users have commented on the great improvements in skin texture, acne, and evenness of their skin tone from using this product.
They mention that the lightweight gel cream formula blends well with their skin, feeling moisturized the following morning without feeling greasy.
Some users have noted the scent of the product being a pleasant eucalyptus smell which feels calming at night.
This retinal product does not tend to cause skin irritation or peeling, unlike other retinoid products that users have used such as Adapelene gels.
Users have mentioned how the product feels silky and hydrating.
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Based on analysis of over 10,000 products. Typical price range defined as the 25th to 75th percentile.
A active priced at $38 is considered mid-range. Generally, actives cost between $24 and $68, and have an average price of $52.
Overview of the highest quality evidence for the active ingredients in this product
Saurat JH, Didierjean L, Masgrau E et al. Topical retinaldehyde on human skin: Biological effects and tolerance. J Invest Dermatol. 1994;103:770–774.
Creidi P, Vienne MP, Ochonisky S et al. Profilometric evaluation of photodamage after topical retinaldehyde and retinoic acid treatment. J Am Acad Dermatol. 1998;39:960–965.
Diridollou S, Vienne MP, Alibert M et al. Efficacy of topical 0.05% retinaldehyde in skin aging by ultrasound and rheological techniques. Dermatology. 1999;199:37–41.
Kwon HS, Lee JH, Kim GM, Bae JM. Efficacy and safety of retinaldehyde 0.1% and 0.05% creams used to treat photoaged skin: A randomized double-blind controlled trial. J Cosmet Dermatol. 2018;17:471–476.
Mordon S, Lagarde JM, Vienne MP et al. Ultrasound imaging demonstration of the improvement of non-ablative laser remodeling by concomitant daily topical application of 0.05% retinaldehyde. J Cosmet Laser Ther. 2004;6:5–9.
Fisher GJ, Datta SC, Talwar HS et al. The molecular basis of sun induced premature ageing and retinoid antagonism. Nature 1996;379:335–338.
Griffiths CEM, Finkel IJ, Tranfaglia MG et al. An in-vivo experimental model for topical retinoid effects on human skin. Br J Dermatol. 1993;29:389–399.
Riahi RR, Bush AE, Cohen PR. Topical retinoids: Therapeutic mechanisms in the treatment of photodamaged skin. Am J Clin Dermatol 2016;17:265–276.
Stein Gold L, Pariser DM, Guenin E. Tretinoin 0.05% Lotion for the Once-Daily Treatment of Moderate and Severe Acne Vulgaris in Females: Effect of Age on Efficacy and Tolerability. J Drugs Dermatol. 2019.
Harper JC, Roberts WE, Zeichner JA, Guenin E, Bhatt V, Pillai R. Novel tretinoin 0.05% lotion for the once-daily treatment of moderate-to-severe acne vulgaris: assessment of safety and tolerability in subgroups. J Dermatol Treat. 2019.
Lain E, Day D, Harper J, Guenin E. Tretinoin 0.05% Lotion for the Once-Daily Treatment of Moderate-to-Severe Acne Vulgaris: Impact of Gender and Race on Efficacy and Safety. J Drugs Dermatol. 2019.
Thielitz A, Abdel-Naser MB, Fluhr JW et al. Topical retinoids in acne-an evidence-based overview. J Dtsch Dermatol Ges. 2008;6:1023–1031.
Thielitz A, Krautheim A, Gollnick H. Update in retinoid therapy of acne. Dermatol Ther. 2006;19:272–279.
Roos TC, Jugert FK, Merk HF, Bickers DR. Retinoid metabolism in the skin. Pharm Rev. 1998;50:315–333.
Wozel G, Chang A, Zultak M et al. The effect of topical retinoids on the leukotriene-B4-induced migration of polymorphonuclear leukocytes into human skin. Arch Dermatol Res. 1991;283:158–161.
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Stratum provides personalized skincare based in dermatology—not marketing hype. Founded by Dr. Usama Syed, a board-certified dermatologist in NYC, Stratum helps you find products that actually work for you.
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